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PAR-3 (1-6) amide, Human Related Products
Catalog No. Peptide Name Size Price M. W Purity Stock
P80163Hu2 PAR-3 (1-6) amide, Human 5mg USD 96 646.75 > 98% In Stock Inquiry
P80163Hu2 PAR-3 (1-6) amide, Human 10mg USD 108 646.75 > 98% In Stock Inquiry
P80163Hu2 PAR-3 (1-6) amide, Human 20mg USD 150 646.75 > 98% In Stock Inquiry
P80163Hu2 PAR-3 (1-6) amide, Human 50mg USD 252 646.75 > 98% In Stock Inquiry
P80163Hu2 PAR-3 (1-6) amide, Human 100mg USD 360 646.75 > 98% 1-3 days Inquiry
P80163Hu2 PAR-3 (1-6) amide, Human 200mg USD 480 646.75 > 98% 3-5 days Inquiry
P80163Hu2 PAR-3 (1-6) amide, Human 500mg USD 600 646.75 > 98% 1-2 weeks Inquiry
P80163Hu2 PAR-3 (1-6) amide, Human 1000mg USD 900 646.75 > 98% 1-2 weeks Inquiry
Overview
Product Name: PAR-3 (1-6) amide, Human(Human)
Synonym:
Catalog No.:P80163Hu2
CAS No.:
Sequence(one-letter):TFRGAP-NH2Trifluoroacetate salt
Sequence(three-letter):Thr-Phe-Arg-Gly-Ala-Pro-NH2Trifluoroacetate salt
Molecular Formula:C29H46N10O7
Molecular Weight:646.75
Purity:> 98%
Storage instructions:Stored at 2-8oC. Store under Desiccating conditions. The product can be stored for up to 12 months.
Description:This peptide is a human PAR-3-derived tethered ligand, which does not activate PAR-3 but rather activates PAR-1 and PAR-2, either in Jurkat or in other PAR-expressing cells.PAR3 Tethered Ligand (Human) / Activates PAR1 and PAR2This peptide is the 1-6 fragment of the protease-activated receptor 3 (PAR-3), which induces ERK activation in human carcinoma cells endogeneously expressing PAR1 and PAR3. This effect is completely abolished by single alanine substitution at positions 3, 4 and 6 in the peptide. PAR-3 allosterically regulates PAR1 signaling by receptor dimerization governing increased endothelial permeability. Targeting of PAR3 may mitigate the effects of PAR1 in activating endothelial responses such as vascular inflammation. However this peptide does not affect VEGF release or expression.
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Note:
1. It is recommended that the concentration of the stock solution be around 1-2 mg of peptide per ml of solution. This is dilute enough to minimize the potential precipitation of the peptides during storage, but concentrated enough to take relatively small volumes (< 100 µl) of aliquots for the assay, and therefore minimizing the effect of the solvents initially used for solubilization.

2. Stability of peptides have no uniform standards. The stability of each peptide depends on its sequence information. We suggest Lyophilized peptides should be stored at -20 °C. It is recommended that peptides containing methionine, cysteine, or tryptophan residues be stored in oxygen-free atmosphere to avoid oxidation.

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