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Product  >  Amyloid  >  Amyloid beta (A4) protein precursor770 (586-595)
Amyloid beta (A4) protein precursor770 (586-595) Related Products
Catalog No. Peptide Name Size Price M. W Purity Stock
P80005Hu1 Amyloid beta (A4) protein precursor770 (586-595) 5mg USD 160 1080.23 > 98% In Stock Inquiry
P80005Hu1 Amyloid beta (A4) protein precursor770 (586-595) 10mg USD 180 1080.23 > 98% In Stock Inquiry
P80005Hu1 Amyloid beta (A4) protein precursor770 (586-595) 20mg USD 250 1080.23 > 98% In Stock Inquiry
P80005Hu1 Amyloid beta (A4) protein precursor770 (586-595) 50mg USD 420 1080.23 > 98% In Stock Inquiry
P80005Hu1 Amyloid beta (A4) protein precursor770 (586-595) 100mg USD 600 1080.23 > 98% 1-3 days Inquiry
P80005Hu1 Amyloid beta (A4) protein precursor770 (586-595) 200mg USD 800 1080.23 > 98% 3-5 days Inquiry
P80005Hu1 Amyloid beta (A4) protein precursor770 (586-595) 500mg USD 1000 1080.23 > 98% 1-2 weeks Inquiry
P80005Hu1 Amyloid beta (A4) protein precursor770 (586-595) 1000mg USD 1500 1080.23 > 98% 1-2 weeks Inquiry
Overview
Product Name: Amyloid beta (A4) protein precursor770 (586-595)(Human)
Synonym:APP770 (586-595) (human); APP-IP; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2
Catalog No.:P80005Hu1
CAS No.:566173-30-6
Sequence(one-letter):H-ISYGNDALMP-OH Trifluoroacetate salt
Sequence(three-letter):H-Ile-Ser-Tyr-Gly-Asn-Asp-Ala-Leu-Met-Pro-OH Trifluoroacetate salt
Molecular Formula:C47H73N11O16S
Molecular Weight:1080.23
Purity:> 98%
Storage instructions:Stored at 2-8oC. Store under Desiccating conditions. The product can be stored for up to 12 months.
Description:Amyloid β/A4 Protein Precursor770 (586-595) (Human) also known as APP-derived inhibitory peptide (APP-IP), efficiently inhibited the activity of gelatinase A (matrix metalloproteinase-2 (MMP-2)) (IC50 = 30 nM), whereas its inhibitory activity towards membrane type 1-matrix metalloproteinase was much weaker (IC50 = 2 µM). The decapeptide had poor inhibitory activity towards gelatinase B, matrilysin or stromelysin (IC50 > 10 µM). APP-IP is likely an active site-directed inhibitor of gelatinase A. Clarification of its mode of action might provide a lead for the design of novel anti-cancer drugs that block specific processes of tumor invasion and angiogenesis.
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Note:
1. It is recommended that the concentration of the stock solution be around 1-2 mg of peptide per ml of solution. This is dilute enough to minimize the potential precipitation of the peptides during storage, but concentrated enough to take relatively small volumes (< 100 µl) of aliquots for the assay, and therefore minimizing the effect of the solvents initially used for solubilization.

2. Stability of peptides have no uniform standards. The stability of each peptide depends on its sequence information. We suggest Lyophilized peptides should be stored at -20 °C. It is recommended that peptides containing methionine, cysteine, or tryptophan residues be stored in oxygen-free atmosphere to avoid oxidation.

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