Orexin | | Other Peptide - Peptide-online

Orexin

Orexin (/ɒˈrɛksɪn/), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. The most common form of narcolepsy, in which the sufferer experiences brief losses of muscle tone (cataplexy), is caused by a lack of orexin in the brain due to destruction of the cells that produce it.

There are only 10,000–20,000 orexin-producing neurons in the human brain, located predominantly in the perifornical area and lateral hypothalamus. They project widely throughout the central nervous system, regulating wakefulness, feeding, and other behaviours. There are two types of orexin peptide and two types of orexin receptor.

Orexin was discovered in 1998 almost simultaneously by two independent groups of researchers working on the rat brain. One group named it orexin, from orexis, meaning "appetite" in Greek; the other group named it hypocretin, because it is produced in the hypothalamus and bears a weak resemblance to secretin, another peptide. The use of both terms is now a practical necessity, as hypocretin is used to refer to the genetic products and orexin is used to refer to the protein products. There is a high affinity between the orexin system in the rat brain and that in the human brain.

Catalog No.	Peptide Name	Sequence	Purity
P80066Mu1	Orexin B, Mouse	RPGPPGLQGRLQRLLQANGNHAAGILTM-NH2	> 98%
P80066Ra1	Orexin B, Rat	RPGPPGLQGRLQRLLQANGNHAAGILTM-NH2	> 98%
P80066Hu1	Orexin B, Human	RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2	> 98%
P80066Hu2	Orexin A, Human	Glp-PLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2...	> 98%
P80066Ce1	Orexin B, Canine	RPGPPGLQGRLQRLLQASGNHAAGILTM-NH2	> 98%

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