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Opioid Related Peptide

Opioid peptides are peptides that bind to opioid receptors in the brain; opiates and opioids mimic the effect of these peptides. Such peptides may be produced by the body itself, for example endorphins. The effects of these peptides vary, but they all resemble those of opiates. Brain opioid peptide systems are known to play an important role in motivation, emotion, attachment behaviour, the response to stress and pain, and the control of food intake.

Opioid-like peptides may also be absorbed from partially digested food (casomorphins, exorphins, and rubiscolins). The opioid food peptides have lengths of typically 4–8 amino acids. The body's own opioids are generally much longer.

Opioid peptides are released by post-translational proteolytic cleavage of precursor proteins. The precursors consist of the following components: a signal sequence that precedes a conserved region of about 50 residues; a variable-length region; and the sequence of the neuropeptides themselves. Sequence analysis reveals that the conserved N-terminal region of the precursors contains 6 cysteines, which are probably involved in disulfide bond formation. It is speculated that this region might be important for neuropeptide processing.

Catalog No.	Peptide Name	Sequence	Purity
P80065Pe1	Gliadorphin-7	H-YPQPQPF-OHTrifluoroacetate salt	> 98%
P80065Pe2	Nociceptin (1-13), amide	FGGFTGARKSARK-NH2Trifluoroacetate salt	> 98%
P80065Mu1	Orphan GPCR SP9155 Agonist P550, Mouse	ASGPLGTLAEELSSYSRRKGGFSFRF-NH2Trifluoroa...	> 98%
P80065Hu1	Orphan GPCR SP9155 Agonist P518, Human	TSGPLGNLAEELNGYSRKKGGFSFRF-NH2Trifluoroa...	> 98%
P80065Pe3	TIPP	Y-Tic-FF	> 98%
P80065Pe4	ff-DNLE-r-NH4Picolyl	DPhe-DPhe-DNLE-DArg-NH4Picolyl	> 98%
P80065Pe5	ffl-DOrn-NHMorpholine	DPhe-DPhe-DLeu-DOrn-NHMorpholine	> 98%
P80065Pe6	[D-Ala2] Deltorphin I	Y-DAla-FDVVG-NH2	> 98%
P80065Pe7	[D-Ala2] Deltorphin II	Y-D-Ala-FEVVG-NH2	> 98%
P80065Pe8	Dermorphin	Y-D-Ala-FGYPS-NH2	> 98%
P80065Pe9	Nociceptin / Orphanin FQ	FGGFTGARKSARKLANQ	> 98%
P80065Pe10	[DArg2,Sar4] Dermorphin (1-4)	Y-DArg-F-Sar	> 98%
P80065Pe11	[DArg2,Lys4]-Dermorphin (1-4), amide	Y-DArg-FK-NH2	> 98%
P80065Pe12	[DArg2] Dermorphin (1-4), amide	Y-D-Arg-FG-NH2	> 98%

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