Endothelin 1 | EDN1 ; ARCND3; ET1; HDLCQ7; PPET1; QME; preproendothelin-1

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Endothelin 1

EDN1 ; ARCND3; ET1; HDLCQ7; PPET1; QME; preproendothelin-1

Endothelin 1 (ET-1), also known as preproendothelin-1 (PPET1), is a protein that in humans is encoded by the EDN1 gene. The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 is one of three isoforms of human endothelin. Preproendothelin is precursor of the peptide ET-1. Endothelial cells convert preproendothelin to proendothelin and subsequently to mature endothelin, which the cells release. Endothelin-1 receptor antagonists (Bosentan) are used in the treatment of pulmonary hypertension. Inhibition of these receptors prevents pulmonary vasculature constriction and thus decreases pulmonary vascular resistance.

Catalog No.	Peptide Name	Sequence	Purity
P80002Hu1	Endothelin 1	H-CSCSSLMDKECVYFCHLDIIW-OH acetate salt ...	> 98%

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